RESEARCH
The department is involved in multiple clinical trials intramural and extramural (Multicentric – National and International). Currently, there are clinical trials for cancer cervix, lung, breast, head & neck and brain tumors and supportive treatment for oral mucositis, emesis and bone health, undertaken with the support of agencies such as the Department of Science and Technology, the Department of Biotechnology, BRNS and AERB. Our Faculty has numerous publications in reputed, indexed and peer reviewed journals from within the country and abroad.
RESEARCH PROJECTS
| Study title | Site | External / Internal Funding |
| ATLAS (Adjuvant Tamoxifen, Longer Against Shorter):International randomised trial of 10 versus 5 years of adjuvant tamoxifen among 11500 women with a history of breast cancer. | Breast | External |
| A Randomised, Double-Blind, Parallel-group, Multicentre, Phase III Study Comparing the Efficacy and Tolerability of Fulvestrant (FASLODEX™) 500 mg with Fulvestrant (FASLODEX™) 250 mg in Postmenopausal Women with Oestrogen Receptor Positive Advanced Breast Cancer Progressing or Relapsing after Previous Endocrine Therapy. | Breast | External |
| Study to assess the efficacy of the blood based gene expression test for Breast Cancer in an Indian population in women with and without breast cancer in various Geographic locations | Breast | External |
| A Phase 2, Randomized, Double masked, placebo- controlled study to evaluate the efficacy of SNX-1012 in Reducing the Duration and Severity of Ulcerative Oral Mucositis in patients receiving Cytotoxic Chemotherapy for Breast or Lung Cancer. | Breast | External |
| Phase I A multicentre, randomized, open label, two-period, two-treatment, two-way crossover, bioequivalence study comparing Capecitabine tablets 500mg (Manufactured by Intas Pharmaceuticals Ltd., India) to the reference listed drug XELODA 500mg tablets (Manufactured by Roche Pharma AG, Germany) in patients of Locally Advanced or Metastatic Breast Cancer or Metastatic Colorectal Cancer under fed condition. | Breast | External |
| Phase III A Randomized, Double Blind, Multicenter, study of Denosumab Compared with Zoledronic Acid ( Zometa) in the treatment of Bone Metastases in subjects with advanced breast cancer. | Breast | External |
| A Phase III Study to Assess the Tolerability and Efficacy of MK-0822 (Odanacatib) in Reducing the Risk of Bone Metastases and Prolonging Disease-Free Survival in Women with Breast Cancer”. | Breast | External |
| A within subject study comparing breast board immobilization with vacloc for radiotherapy in breast cancer: setup precision, treatment time and patient comfort. | Breast | Internal |
| Phyllodes tumor of the breast – A retrospective analysis to predict the factors influencing local recurrence and distant metastases. | Breast | Internal |
| Level of anxiety in breast cancer patients receiving loco-regional radiation therapy and its correlation with inter fraction variations observed during delivery of treatment. | Breast | Internal |
| Obesity and breast cancer – a single institution experience | Breast | Internal |
| Over expression of replication factor subunit 3 (RFC3) is associated with adverse outcome in Triple Negative Breast Cancers (TNBC). | Breast | Internal |
| phase-II, Randomised, Double-blind, Placebo-controlled, Multi-centre study to assess the efficacy and safety of AZD8931 in combination with Anastrozole, compared to Anastrozole alone, in post menopausal women with Hormone receptor positive, endocrine therapy-naïve, Locally-advanced or metastatic breast cancer (MINT) | Breast | External |
| Study to assess the efficacy of the blood based gene expression test for Breast Cancer in an Indian population in women with and without breast cancer in various Geographic locations. | Breast | Internal |
| Phase I A multicentre, randomized, open label, two period, two treatment, two way crossover, bioequivalence study comparing Capecitabine tablets USP 500 mg (Manufactured by: Intas Pharmaceutical Ltd) to the reference listed drug XELODA® (capecitabine) tablets 500 mg (Distributed by: Roche Laboratories Inc., New Hersey 07110) in patients of Breast Cancer or Colorectal cancer under fed condition. | Breast | External |
| Prevention of Radiation skin reactions in breast cancer women undergoing radiation therapy by using steroid cream and barrier film methods and to look at safety and efficacy | Breast | Internal |
| Comparison of cardiac and lung doses with Deep Inspiratory Breath Hold (DIBH) and free breathing in patients receiving radiotherapy for carcinoma left breast – A pilot study | Breast | Internal |
| A Randomized, Active Therapy Controlled Phase 2 Study to Assess the Safety and Efficacy of ADXS11-001 with or without Cisplatin as 2nd Line Therapy for the Treatment of Recurrent Cervix Cancer. | Gynaecology | External |
| Phase III A Phase 3 Randomised comparison of Concurrent Gemcitabine, Cisplatin, and Radiation Followed by Adjuvant Gemcitabine and Cisplatin and Radiation in Cancer of the Cervix Stages II B to IV A. | Gynaecology | External |
| Ph.D thesis: Investigation on the role of ultrafractionated low dose radiation and chemotherapy in carcinoma cervix. | Gynaecology | Internal |
| Quantification of DNA Double Strand Break (DSB) with radiation and chemotherapy in cervix cancer cells: in-vitro study”. | Gynaecology / Medical Physics | Internal |
| A Multicenter Phase II study of Gemcitabine, Paclitaxel and Cisplatin in chemotherapy naïve advanced Ovarian Cancer. B9E-MC-S163 | Gynaecology | External |
| An International, Multi-Center, Randomized, Double Blind Placebo Controlled Phase II Study to Evaluate the Safety and Efficacy of Lucanthone Administered as an Adjunct to Radiation and Temozolomide for Primary Therapy of Glioblastoma Multiforme. | Neuro Oncology | External |
| A Two- Way crossover experimental evaluation of relative bioavailabilities of two formulations of Temozolomide 250 mg capsules in adult human male and/or female patients under fasting conditions | Neuro Oncology | External |
| DBT-PET-MRI Automatic Tumor Detection and Recognition (ATR) 1. PET-MRI Automatic Tumor Detection and Recognition (ATR) | Neuro Oncology | Internal |
| Phase III A randomized controlled comparative trial to evaluate the efficacy and safety of 2-Deoxy –D- Glucose (2DG) as a radiomodifier in the treatment of Glioblastoma Multiforme. | Neuro Oncology | External |
| Phase II An Open Label, Prospective, Multicentric Study to Evaluate the Safety And Efficacy of BIOMAb-EGFRTM (Nimotuzumab) As Induction and Maintenance Therapy in Combination With Radiotherapy Plus Temozolomide (Concomitant & Adjuvant) In Indian Patients With Glioblastoma Multiforme. | Neuro Oncology | External |
| A Pilot dosimetric study to compare non coplanar dynamic conformal arc (DCA), static conformal arc (SCA) and static conformal field (SCF) stereotactic techniques for Cranio pharyngioma and Pituitary tumors. | Neuro Oncology | Internal |
| Patient reported health related quality of life (HRQOL) and neurocognitive function (NCF) assessment in patients with high grade glioma. | Neuro Oncology | Internal |
| Magnetic Resonance Spectroscopy Based Target Volume Delineation In High Grade Gliomas | Neuro Oncology | Internal |
| Outcome of patients with GBM who were treated with surgery followed by chemoradiotherapy and adjuvant chemotherapy | Neuro Oncology | Internal |
| Molecular profile of tumours with oligodendroglial morphology – clinical relevance. | Neuro Oncology | Internal |
| Somatostatin receptor imgaing with Ga 68 Dotatate PET and metabolic imaging with FDG PET in the management of growth hormone secreting pituitary adenoma | Neuro Oncology | Internal |
| Outcome of radiotherapy for pituitary adenomas | Neuro Oncology | Internal |
| Outcome of patients with vestibular schwannoma treated with linac based stereotactic radiosurgery | Neuro Oncology | Internal |
| Co-relation of radiation dose to anal sphincter and anal manometry changes in locally advanced rectal cancer patients undergoing preoperative long course chemoradiation therapy. | Colorectal | Internal |
| MRI downstaging, pathological response and microsatellite instability status in patient’s with signet ring cell carcinoma rectum undergoing preoperative long course chemoirradiation. | Colorectal | Internal |
| A Multicenter, Phase II/III Study to Assess Radiation Induced Mucositis in Patients with Locally Advanced Squamous Cell Carcinoma of the Head And Neck Administered Cisplatin And Radiation with or without P276-00. | Head and Neck | External |
| Phase III double-blind, placebo-controlled study of post-operative adjuvant concurrent chemoradiotherapy (CTRT) with or without nimotuzumab for stage III/IV head and neck squamous cell cancer (HNSCC). | Head and Neck | External |
| Phase I/II An Open Label, Multicenter Phase I/II Study Of Selective Cyclin Dependent Kinase Inhibitor P276-00 In Combination With Radiation In Subjects With Recurrent And/Or Locally Advanced Squamous Cell Carcinoma Of Head And Neck. | Head and Neck | External |
| Phase II International randomized study to evaluate the addition of Docetaxel to the combination of Cisplatin -5 flurouracil (TCF) vs. Cisplatin -5 flurouracil (CF) in the induction treatment of nasopharyngeal carcinoma (NPC) in children and adolescents. | Head and Neck | External |
| Randomized Controlled Trial Assessing Addition of Neoadjuvant and Maintenance Oral Metronomic Chemotherapy to Standard Surgery and Adjuvant Therapy in Stage III/IV Operable Oral Cancers. | Head and Neck | External |
| A Phase II Randomized, Double Blind, Placebo Controlled, Multicenter Comparative Study of ZD1839 250 mg or 500 mg (IressaTM) given either continuously orconcomitantly with Cisplatin plus Radiotherapy for the treatment of patients with previously untreatedunresected Late Stage III/IV Non-metastatic Head & Neck Squamous Cell Carcinoma. | Head and Neck | External |
| A Randomized, Double-Blind, Placebo-controlled, Multicenter, Phase II Study of Oral Lapatinib in combination with concurrent Radiotherapy and Cisplatin versusRadiotherapy and Cisplatin versus Radiotherapy and Cisplatin alone, in Subjects with Stage III and IV A,B Squamous Cell Carcinoma of the Head and Neck (SCCHN) | Head and Neck | External |
| Phase III A Randomized phase 3 study of Pemetrexed in Combination with Cisplatin Versus Cisplatin Monotherapy in patients with Recurrent or Metastatic Head and Neck Cancer. | Head and Neck | External |
| Phase II A Phase 2 Randomized, Double-Blind, Placebo-Controlled, Active Comparator, 12-Week Study to Evaluate the Safety and Efficacy of Pilocarpine Buccal Inserts and Pilocarpine Hydrochloride Oral Tablets in Patients with Xerostomia secondary to Radiation Therapy for Head and Neck Cancer. | Head and Neck | External |
| Disease outcome in oral and oropharyngeal cancers based on combined virological and molecular risk stratification. | Head and Neck | Internal |
| Radiation dose differences seen between two different modalities of delivering radiation Therapy in head and neck cancers. | Head and Neck | Internal |
| Association between the radiation doses to the pharyngeal constrictors and swallowing Dysfunction and patients’ quality of life following chemo irradiation for head and neck cancers. | Head and Neck | Internal |
| Does serial exit dose fluence analysis, identify need for adaptive re-planning in Intensity Modulated Radiotherapy of locally advanced Head and Neck Cancers. | Head and Neck / Medical Physics | Internal |
| Patterns of Care and Outcomes in Head and Neck Malignancies Treated with Intensity Modulated Radiotherapy. | Head and Neck | Internal |
| Standard follow up program (sfp) for head and neck cancer patients treated with curative primary or postoperative radiotherapy or chemoradiation / radiomics of the head and neck: treatment outcome prediction using non-invasive quantitative imaging features (Collaboration with MAASTRO, Netherlands). | Head and Neck | Internal |
| Randomized Controlled Trial Assessing Addition of Neoadjuvant and Maintenance Oral Metronomic Chemotherapy to Standard Surgery and Adjuvant Therapy in Stage III/IV Operable Oral Cancers. | Head and Neck | Internal |
| To study palliation of symptoms by a hypo fractionated radiotherapy schedule in Inoperable Squamous Cell Cancers of the oral cavity. | Head and Neck | Internal |
| Comparison of CT based and integrated F-18 FDG, PET CT scan based Gross Tumour Volume in Head and Neck Cancers and evaluation of segmentation methods for delineation of the target on PET CT scan. | Head and Neck | Internal |
| Association between the radiation dose to the pharyngeal constrictors and swallowing dysfunction and patients’ quality of life following chemo irradiation for head and neck cancers. | Head and Neck | Internal |
| A Phase 3, randomized, double blinded, placebo-controlled study of oral talactoferin in addition to best supportive cere in patients with non-small cell lung cancer who have failed two or more proir treatment regimens. | Lung | External |
| Patient Attitude and Lung Cancer Survival-Prospective Observational Study in Advanced NSCLC. B9E-AA-JHSH. | Lung | External |
| Observational study in Advanced Carcinoma Lung treated with combination chemotherapy with Gemcitabine and Cisplatin | Lung | External |
| Development of two-dimensional EPID-based in vivo exit dosimetry for intensity modulated radiotherapy and dosimetric model for midplane dosimetry”. | Medical Physics | Internal |
| Determination of output factor for small radiation fields with different detectors and gafchromic film | Medical Physics | Internal |
| Evaluation of dosimetric characteristics of OCTAVIUS 1500 detector array. | Medical Physics | Internal |
| Efficacy of progressive muscle relaxation on anxiety, fatigue and quality of sleep among cancer patients undergoing radiation. | Nursing | Internal |
| A descriptive study to assess the distress and coping strategies of patients undergoing radiation therapy with selected cancers in Christian Medical College, Vellore. | Nursing | Internal |
| Cancer Registry – Demographic Registry Project. | Others | Internal |
| Standardisation of clonogenic assay in Hela cell lines | Others | Internal |
| A Phase I/II Study to Evaluate Safety and Efficacy of P276-00 in Combination with Gemcitabine in Patients with Cancer of Pancreas. | Pancreas | External |
| Phase III A Randomized, Double Blind, Multicenter, study of Denosumab Compared with Zoledronic Acid ( Zometa) in the treatment of Bone Metastases in subjects with advanced Prostate cancer. | Prostate | External |
| A Pivotal trial to determine the efficiency & safety of AP23573 when administered as Maintenance therapy to Patients with Metastatic Soft Tissue or Bone Sarcoma. | Sarcomas | External |
| Intermediate and High grade Fibroblastic and Myofibroblastic tumors – A retrospective analysis. | Sarcomas | Internal |
| Diffusion weighted magnetic resonance imaging for predicting clinical and pathologic response to neo adjuvant chemo radiotherapy in esophageal cancer. | Thorax | Internal |
| Radiation Physics Projects (External) | ||
| Patient Specific Dose Calculation using Cone Beam CT with local and Global HU correction strategies and deformable image registration based adaptive Radiotherapy Principal Investigator: Dr Paul Ravindran | Funded by the Atomic Energy Regulatory Board, Govt. of India (2016-2019) | |
| To Investigate the relationship between end to end accuracy and quality assurance extent and depth in radiotherapy Principal Investigators: Dr Paul Ravindran | Funded by International Atomic Energy Agency (2013-2017) | |
| Investigation of radiation Dose to patient during image guidance in radiotherapy Principal Investigator: Dr Paul Ravindran | Funded by Board of Research in Nuclear Sciences, DAE, Govt of India (Completed in 2013) | |
| Development of a system for 3 D image guidance for Radiation therapy Principal Investigator: Dr Paul Ravindran | Funded by the Life sciences research board, DRDO, Govt of India (Completed in 2009) | |
| Investigation on the use of photo stimulable phosphor plates for portal imaging and dosimetry Principal Investigator: Dr Paul Ravindran | Funded by the Atomic Energy Regulatory Board, Govt. of India (Completed in 2008) | |
| Design and Development of Multileaf Collimator for Telecobalt Unit Principal Investigator: Dr Rabi Raja Singh | Funded by Board of Nuclear Science and Research, DAE, Govt. of India (Completed in 2008) | |
| Development of Gel Dosimetry for 3 D dosimetry in Radiation Therapy Principal Investigator: Dr Paul Ravindran | Funded by Atomic Energy Regulatory Board, Govt. of India (Completed in 2004) | |
| Development of microprocessor controlled 3-Dimensional Radiation Field Analyzer and TL dosimetry method for Irregular fields Principal Investigator: Dr Paul Ravindran | Funded by Board of Research in Nuclear Sciences, DAE, Govt. of India (Completed in 1995) | |